2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-116069
    Propargyl-PEG1-NH2 122116-12-5 98.80%
    Propargyl-PEG1-NH2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG1-NH2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG1-NH2
  • HY-138734
    Propargyl-PEG2-NHS ester 2512228-06-5 ≥98.0%
    Propargyl-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG2-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-NHS ester
  • HY-126891
    Bis-PEG3-acid 96517-92-9
    Bis-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bis-PEG3-acid
  • HY-141336
    α-Lipoic acid-NHS 40846-94-4 ≥98.0%
    α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    α-Lipoic acid-NHS
  • HY-140988
    Mal-NH2 TFA 146474-00-2
    Mal-NH2 (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-NH2 TFA
  • HY-140820
    Bromo-PEG3-azide 1446282-43-4
    Bromo-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Bromo-PEG3-azide
  • HY-140757
    Azido-PEG5-NHS ester 1433996-86-1 ≥98.0%
    Azido-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-NHS ester
  • HY-119429
    Bis-PEG4-acid 31127-85-2 ≥98.0%
    Bis-PEG4-acid is a PEG PROTAC linker.
    Bis-PEG4-acid
  • HY-133378
    Biotin-PEG24-NHS ester
    Biotin-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG24-NHS ester
  • HY-126974
    Propargyl-PEG3-NHS ester 1428629-71-3
    Propargyl-PEG3-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG3-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG3-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG3-NHS ester
  • HY-130474
    Azido-PEG6-NHS ester 2055014-64-5 98.85%
    Azido-PEG6-NHS ester is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG6-NHS ester is also a PEG- and Alkyl/ether based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-NHS ester
  • HY-138469
    NH2-PEG3-C6-Cl 1261350-60-0
    NH2-PEG3-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG3-C6-Cl
  • HY-40144
    Azetidin-3-ol hydrochloride 18621-18-6 ≥98.0%
    Azetidin-3-ol hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidin-3-ol hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthes PROTAC.
    Azetidin-3-ol hydrochloride
  • HY-141233
    Dodecaethylene glycol 6790-09-6 99.93%
    Dodecaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Dodecaethylene glycol
  • HY-140585
    N-DBCO-N-bis(PEG2-C2-NHS ester) 2128735-29-3
    N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-DBCO-N-bis(PEG2-C2-NHS ester) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    N-DBCO-N-bis(PEG2-C2-NHS ester)
  • HY-130194
    Azido-PEG5-CH2CO2H 217180-81-9 99.60%
    Azido-PEG5-CH2CO2H is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-CH2CO2H is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-CH2CO2H
  • HY-W040165
    Amino-PEG3-C2-acid 784105-33-5 99.94%
    Amino-PEG3-C2-acid is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG3-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG3-C2-acid
  • HY-130180
    Propargyl-PEG6-NH2 1198080-04-4 99.69%
    Propargyl-PEG6-NH2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-NH2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG6-NH2
  • HY-W040168
    Amino-PEG2-C2-acid 791028-27-8 ≥98.0%
    Amino-PEG2-C2-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG2-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG2-C2-acid
  • HY-W034599
    Boc-C14-COOH 843666-27-3 ≥98.0%
    Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C14-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-C14-COOH
PROTAC Linkers Isoform Comparison

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